High-affinity choline transporter 1

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August undefined, 2024

WebHigh affinity choline transporter 1, Hemicholinium-3-sensitive choline transporter, CHT, Solute carrier family 5 member 7. eCl@ss: 32160702. NACRES: NA.41. Recommended Products. Slide 1 of 10. 1 of 10. Sigma-Aldrich. AV41516. Anti-SLC22A1 (AB1) antibody produced in rabbit. IgG fraction of antiserum. WebACh depends on the activity of a high affinity choline trans-porter (CHT1) that is necessary to supply choline for ACh ... Rylett, R.J. & Ferguson, S.S. (2005) Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif. JNeurochem94,86–96. Ribeiro, F.M., Black, S.A., Prado, V.F ...

The High-Affinity Choline Transporter: A Critical Protein for ...

WebThe high-affinity choline transporter CHT1 mediates choline uptake, the rate-limiting and regulatory step in acetylcholine synthesis at cholinergic presynaptic terminals.CHT1-medated choline uptake is specifically inhibited by hemicholinium-3, which is a type of choline analog that acts as a competitive inhibitor.Although the substrate choline and … Web29 de jul. de 2014 · Highaffinity choline transporter 1 is involved in choline transport from the extracellular space to the neuron (48). Innexin 2 is required for the regulation of neuronal networks (49).... simply fit bamberg

Frontiers A comparative review on the well-studied GAT1 and the ...

WebCTL1 is a high-affinity and CTL2 is a low-affinity Etn transporter We studied the kinetics of Etn transport in monkey COS-7 cells and control (Ctrl) and CTL1 deficient (M1= SLC44A1ΔAsp517 and M2= SLC44A1Ser126) primary human fibroblasts. WebAt high concentrations, choline is transported primarily by a low-affinity and Na + -independent system that is inhibited by hemicholinium-3 (HC3) 10 with a high Ki of … WebProtein target information for High affinity choline transporter 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay … simply fit bars

IJMS Free Full-Text Molecular and Functional Analysis of Choline ...

Anti-Choline Transporter Antibody, high affinity AB5966

WebThe high-affinity choline transporter (CHT1), which is specifically expressed in cholinergic neurons, constitutes a rate-limiting step for acetylcholine synthesis. We have found that … Web8 de mar. de 2006 · The high-affinity choline transporter at the molecular level. Despite the fact that the high-affinity choline uptake system was described in the 1960s, the … simply fit berkshireWebIn cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting step in acetylcholine synthesis. Using information provided by the Caenorhabditis … rays restaurant in seward ak

"Web10 de jun. de 2005 · Maintenance of acetylcholine synthesis depends on the effective functioning of a high-affinity sodium-dependent choline transporter (CHT1). Recent studies have shown that this transporter is predominantly localized inside the cell, unlike other neurotransmitter transporters, suggesting that the trafficking of CHT1 to and from … " - High-affinity choline transporter 1

High-affinity choline transporter 1

Blockage of High-Affinity Choline Transporter Increases Visceral ...

Web1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium … Web1 de out. de 2002 · High-affinity choline transporter 1. Gene. ChT. Status. UniProtKB reviewed (Swiss-Prot) Organism. Drosophila melanogaster ... Function. function. Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity). By ...

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WebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high … Web29 de jul. de 2014 · Highaffinity choline transporter 1 is involved in choline transport from the extracellular space to the neuron (48). Innexin 2 is required for the regulation of …

WebPeroxynitrite donor SIN-1 modifies high-affinity choline transporter activity by modifying its intracellular trafficking Journal of Neuroscience April 18, 2012 Other ... WebCHT1 protein is mainly found in intracellular organelles, such as endosomal compartments and synaptic vesicles. The presence of CHT1 at the plasma membrane is limited by …

WebThe high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. It is a cell membrane … WebThe High-Affinity Choline Transporter: A Critical Protein for Sustaining Cholinergic Signaling as Revealed in Studies of Genetically Altered Mice M. H. Bazalakova & R. D. Blakely Chapter 1676 Accesses 28 Citations Part of the Handbook of Experimental Pharmacology book series (HEP,volume 175) Abstract

Web5 de mai. de 2024 · To examine the action of tetrahydropyrimidines on the nematode high-affinity choline transporter, we generated HEK293 cell lines stably expressing the high-affinity choline transporter from C. elegans (CHO-1), the ortholog of CHT1 (Okuda et al., 2000), and measured the high-affinity choline uptake activity in the presence of …

Web1 de jan. de 2024 · The high-affinity choline transporter was first cloned in 2000 and designated as CHT1 (Okuda et al. 2000 ). Structure and Functional Properties of CHT1 CHT1 is a member of the solute carrier family 5 (SLC5, sodium/glucose cotransporter family) and is also known as SLC5A7. It shares 20–25% amino acid sequence homology with … simplyfit arbonWeb3 de nov. de 2000 · The presence of the high-affinity choline transporter Choline transporter 1 in nerve fibers and epithelial cells in the human and rat skin supporting the … simply fit austinWeb8 de mar. de 2006 · The high-affinity choline transporter at the molecular level. Despite the fact that the high-affinity choline uptake system was described in the 1960s, the genes for the high-affinity choline transporter proteins (CHT1) of Caenorhabditis elegans and rat have only recently been cloned (Okuda et al. 2000). simply fit bars melaleucaWeb22 de jul. de 2024 · The first transporter is high-affinity choline transporter 1 (CHT1) that is expressed in cholinergic neurons and is linked to acetylcholine synthesis, which has a … simply fit and funWeb1 de mar. de 2001 · High affinity choline transporter 1 Alternative names Hemicholinium-3-sensitive choline transporter ( CHT) Solute carrier family 5 member 7 Gene names … rays rhymesWebThe Na(+)-dependent uptake of choline by CHT1 is the rate-limiting step for synthesis of acetylcholine. CHT1 is the integral membrane protein with 13 transmembrane segments, … rays restaurant in wellsvilleWeb18 de jan. de 2010 · The cho-1 gene in Caenorhabditis elegans encodes a high-affinity plasma-membrane choline transporter believed to be rate limiting for acetylcholine (ACh) synthesis in cholinergic nerve terminals. simply fit bands